Services that require precertification
As of July 1, 2025, this list applies to all AmeriHealth Pennsylvania HMO and POS products, including Flex products
This applies to services performed on an elective, nonemergency basis
Because a service or item is subject to precertification, it does not guarantee coverage. The terms and conditions of your benefit plan must be reviewed to determine if any of these services or items are excluded.
You can find additional information regarding preapproval/precertification, member cost-sharing and prescription drug coverage on the AmeriHealth
Preapproval/Precertification Requirements and Member Cost-Sharing page.
All home-care services (including infusion therapy in the home)
Inpatient services
- Acute rehabilitation admissions
- Elective surgical and nonsurgical inpatient admissions
- Inpatient hospice admissions
- Long term acute care (LTAC) facility admissions
- Skilled nursing facility admissions
Cardiology procedures
Precertification is performed by Carelon Medical Benefits Management, an independent company.
- Arterial ultrasound
- Diagnostic coronary angiography
- Percutaneous coronary intervention
Procedures
- Cochlear implant surgery and associated supplies/bone-anchored (osseointegrated) hearing aids, implantable bone conduction hearing aids
69714, 69715, 69717, 69718, 69930, L8614, L8619, L8627, L8628, L8629, L8690, L8691, L8692, L8693
- Obesity surgery
43644, 43645, 43659, 43770, 43771, 43772, 43773, 43774,43775, 43843, 43845, 43846, 43847, 43848, 43886, 43887, 43888, 43999
Musculoskeletal Procedures
Precertification is performed by Carelon Medical Benefits Management, an independent company. For additional information, refer to the current version of Medical Policy #00.01.66: Musculoskeletal Services.
- Bone graft substitutes and bone morphogenetic proteins for spine surgery
- Cervical decompression with or without fusion
- Cervical disc arthroplasty
- Hip arthroplasty
- Hip arthroscopy and open procedures
- Knee arthroplasty
- Knee arthroscopy and open procedures
- Lumbar disc arthroplasty
- Lumbar discectomy, foraminotomy, and laminotomy
- Lumbar fusion and treatment of spinal deformity (including scoliosis and kyphosis)
- Lumbar laminectomy
- Meniscal allograft transplantation of the knee
- Shoulder arthroplasty
- Shoulder arthroscopy and open procedures
- Treatment of osteochondral defects
- Vertebroplasty/Kyphoplasty
Interventional pain management services
Precertification is performed by Carelon Medical Benefits Management, an independent company. For additional information, refer to the current version of Medical Policy #00.01.66: Musculoskeletal Services.
- Epidural Injection Procedures and Diagnostic Selective Nerve Root Blocks
- Paravertebral Facet Injection/Nerve Block/Neurolysis
- Regional Sympathetic Nerve Block
- Sacroiliac joint injections
- Implanted spinal cord stimulators
Reconstructive procedures and potentially cosmetic procedures
- Blepharoplasty/ptosis repair
15820, 15821, 15822, 15823,
67900, 67901, 67902, 67903, 67904, 67906, 67908, 67909
- Bone graft, genioplasty and mentoplasty
21120, 21121, 21122, 21123
- Breast Reconstruction
11920, 11921, 11922, 11970, 11971, 15271, 15272, 15769, 15771, 15772, 15773, 15774, 15777, 19300, 19350, 19355, 19357, 19361, 19364, 19367, 19368, 19369, 19380, Q4100, Q4107, Q4116, Q4130, Q4142, Q4143, S2066, S2067, S2068
- Breast Reduction
15877, 19318
- Breast Augmentation/Mammoplasty
19325
- Breast Mastopexy
19316
- Insertion of Breast Implants
19340, 19342, 19396
- Removal of Breast Implants
19328, 19330, 19370, 19371
- Canthopexy/Canthoplasty
21280, 21282, 67950
- Cervicoplasty
17999
- Chemical peels
15788, 15789, 15792, 15793
- Dermabrasion
15780, 15781, 15782, 15783
- Excision of excessive skin and/or subcutaneous tissue
15830, 15832, 15833, 15834, 15835, 15836, 15837, 15838, 15839
- Gender Affirming interventions
11920, 11921, 11922, 11960, 15877, 17380, 19303, 53430,54125, 54400, 54401, 54405, 54520, 54660, 54690, 55175, 55180, 57106, 57110, 58150, 58180, 58260, 58262, 58275, 58290, 58291, 58541, 58542, 58543, 58544, 58550, 58552, 58553, 58554, 58570, 58571, 58572, 58573, 58720
- Genetically and bio-engineered skin substitutes for wound care
A2001, A2002, A2004, A2007, A2008, A2009, A2010, A2011, A2012, A2013, A2014, A2015, A2016, A2018, A2019, A2021,A2022, A2023, A2024, A2025, A2026, A2027, A2028, A2030, A2031, A2032, A2033, A2034, A2035, Q4100, Q4101, Q4102, Q4103, Q4104, Q4105, Q4106, Q4107, Q4108, Q4110, Q4111, Q4113, Q4114, Q4115, Q4117, Q4118, Q4121, Q4122, Q4123, Q4124, Q4126, Q4127, Q4128, Q4132, Q4133, Q4134, Q4135, Q4136, Q4137, Q4139, Q4140, Q4141, Q4145, Q4146, Q4147, Q4148, Q4149, Q4151, Q4152, Q4153, Q4154, Q4155, Q4156, Q4157, Q4158, Q4159, Q4160, Q4161, Q4162, Q4163, Q4164, Q4165, Q4166, Q4167, Q4168, Q4169, Q4170, Q4171, Q4173, Q4174, Q4175, Q4176, Q4177, Q4178, Q4179, Q4180, Q4181, Q4182, Q4199, Q4205, Q4206, Q4208, Q4209, Q4211, Q4214, Q4215, Q4216, Q4217, Q4218, Q4219, Q4220, Q4221, Q4222, Q4224, Q4225, Q4227, Q4228, Q4229, Q4230, Q4232, Q4233, Q4234, Q4235, Q4236, Q4237, Q4238, Q4239, Q4245, Q4246, Q4247, Q4248, Q4249, Q4250, Q4251, Q4252, Q4253, Q4254, Q4255, Q4256, Q4257, Q4258, Q4259, Q4260, Q4261, Q4262, Q4263, Q4264, Q4265, Q4266, Q4267, Q4268, Q4269, Q4270, Q4271, Q4272, Q4273, Q4274, Q4275, Q4276, Q4278, Q4279,Q4280, Q4281, Q4282, Q4283, Q4284, Q4287, Q4288, Q4289, Q4290, Q4291, Q4292, Q4293, Q4294, Q4295, Q4296, Q4297, Q4298, Q4299, Q4300, Q4301, Q4302, Q4303, Q4304, Q4305, Q4306, Q4307, Q4308, Q4309, Q4310, Q4311, Q4312, Q4314, Q4317, Q4318, Q4319, Q4320, Q4321, Q4322, Q4325, Q4326, Q4327, Q4328, Q4329, Q4330, Q4331, Q4332, Q4333, Q4336, Q4337, Q4338, Q4339, Q4340, Q4341, Q4342, Q4344, Q4354, Q4355, Q4356, Q4357, Q4358, Q4359, Q4361, Q4362, Q4363, Q4364, Q4365, Q4366, Q4367, Q4368, Q4370, Q4371, Q4372, Q4373, Q4375, Q4376, Q4377, Q4378, Q4379, Q4380, Q4382
- Hair transplant
15775, 15776
- Keloid removal
13100, 13101, 13102, 13120, 13121, 13122, 13131, 13132, 13133, 13151, 13152, 13153, 14000, 14001, 14020, 14021, 14040, 14041, 14060, 14061, 14301, 14302, 15002, 15003, 15004, 15005, 15040, 15050, 15100, 15101, 15110, 15111, 15115, 15116, 15120, 15121, 15130, 15131, 15135, 15136, 15150, 15151, 15152, 15155, 15156, 15157, 15200, 15201, 15220, 15221, 15240, 15241, 15260, 15261, 15271, 15272, 15273, 15274, 15275, 15276, 15277, 15278, 15570, 15572, 15574, 15576, 15600, 15610, 15620, 15630, 15650, 15731, 15733, 15734, 15736, 15738, 15740, 15750, 15756, 15757, 15758, 15760, 15770, 15780, 15781, 15782, 15783, 15786, 15787, 31830
- Lipectomy, liposuction, or any other excess fat-removal procedure
15832, 15833, 15834, 15835, 15836, 15837, 15838, 15839, 15876, 15877, 15878, 15879
- Otoplasty
13151, 13152, 13153, 14060, 14061, 15260, 15261, 21235, 69300, 69399
- Rhinoplasty
30400, 30410, 30420, 30430, 30435, 30450
- Rhytidectomy
15824, 15825, 15826, 15828, 15829, 15838, 15839, 15876
- Scar revision
13100, 13101, 13102, 13120, 13121, 13122, 13131, 13132, 13133, 13151, 13152, 13153, 14000, 14001, 14020, 14021, 14040, 14041, 14060, 14061, 14301, 14302, 15002, 15003, 15004, 15005, 15040, 15050, 15100, 15101, 15110, 15111, 15115, 15116, 15120, 15121, 15130, 15131, 15135, 15136, 15150, 15151, 15152, 15155, 15156, 15157, 15200, 15201, 15220, 15221, 15240, 15241, 15260, 15261, 15271, 15272, 15273, 15274, 15275, 15276, 15277, 15278, 15570, 15572, 15574, 15576, 15600, 15610, 15620, 15630, 15650, 15731, 15733, 15734, 15736, 15738, 15740, 15750, 15756, 15757, 15758, 15760, 15770, 15780, 15781, 15782, 15783, 15786, 15787, 31830
- Skin closures
13100, 13101, 13102, 13120, 13121, 13122, 13131, 13132, 13133, 13151, 13152, 13153, 14000, 14001, 14020, 14021, 14040, 14041, 14060, 14061, 14301, 14302, 15002, 15003, 15004, 15005, 15040, 15050, 15100, 15101, 15110, 15111, 15115, 15116, 15120, 15121, 15130, 15131, 15135, 15136, 15150, 15151, 15152, 15155, 15156, 15157, 15200, 15201, 15220, 15221, 15240, 15241, 15260, 15261, 15271, 15272, 15273, 15274, 15275, 15276, 15277, 15278, 15570, 15572, 15574, 15576, 15600, 15610, 15620, 15630, 15650, 15731, 15733, 15734, 15736, 15738, 15740, 15750, 15756, 15757, 15758, 15760, 15770
- Surgery for varicose veins, including perforators and sclerotherapy
36465, 36466, 36468, 36470, 36471, 36475, 36476, 36478, 36479, 36482, 36483, 37500, 37700, 37718, 37722, 37735, 37760, 37761, 37765, 37766, 37780, 37785, 37799, S2202
Elective (nonemergency) ground, air, and sea ambulance transportation
A0140, A0426, A0428, A0430, A0431,
A0434, S9960, S9961
Outpatient private-duty nursing
S9123, S9124
Day rehabilitation programs
0931, 0932
Outpatient radiation therapy
Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).
Radiology
Precertification is performed by Carelon Medical Benefits Management, an independent company.
- CT
- CTA
- Echocardiography services
- Testing transthoracic echocardiography (TTE)
- Stress echocardiography (SE)
- Transesophageal echocardiography (TE)
- MRA
- MRI
- Nuclear cardiology
- PET scans
Prosthetics/orthoses including:
- Custom ankle-foot orthoses
L1900, L1904, L1907, L1920, L1940, L1945, L1950, L1960, L1970, L1980, L1990, L2106, L2108, L4631
- Custom knee-ankle-foot orthoses
L2000, L2005, L2010, L2020, L2030, L2034, L2036, L2037, L2038, L2126, L2128
- Custom knee braces
L1834, L1840, L1844, L1846, L1860
- Custom limb prosthetics including accessories/components
L5010, L5020, L5050, L5060, L5100, L5105, L5150, L5160, L5200, L5210, L5220, L5230, L5250, L5270, L5280, L5301, L5312, L5321, L5331, L5341, L5510, L5520, L5530, L5535, L5540, L5560, L5570, L5580, L5585, L5590, L5595, L5600, L5610, L5611, L5613, L5614, L5615, L5616, L5617, L5618, L5620, L5622, L5624, L5626, L5628, L5629, L5630, L5631, L5632, L5634, L5636, L5637, L5638, L5639, L5640, L5642, L5643, L5644, L5645, L5646, L5647, L5648, L5649, L5650, L5651, L5652, L5653, L5654, L5655, L5656, L5658, L5661, L5665, L5666, L5668, L5670, L5671, L5672, L5673, L5676, L5677, L5678, L5679, L5680, L5681, L5682, L5683, L5684, L5685, L5686, L5688, L5690, L5692, L5694, L5695, L5696, L5697, L5698, L5699, L5700, L5701, L5702, L5703, L5704, L5705, L5706, L5707, L5710, L5711, L5712, L5714, L5716, L5718, L5722, L5724, L5726, L5728, L5780, L5781, L5782, L5783, L5785, L5790, L5795, L5810, L5811, L5812, L5814, L5816, L5818, L5822, L5824, L5826, L5827, L5828, L5830, L5840, L5841, L5845, L5848, L5850, L5855, L5856, L5857, L5858, L5859, L5910, L5920, L5925, L5926, L5930, L5940, L5950, L5960, L5962, L5964, L5966, L5968, L5970, L5971, L5972, L5973, L5974, L5975, L5976, L5978, L5979, L5980, L5981, L5982, L5984, L5985, L5986, L5987, L5988, L5990, L5999, L6000, L6010, L6020, L6028, L6029, L6030, L6031, L6032, L6033, L6037, L6050, L6055, L6100, L6110, L6120, L6130, L6320, L6350, L6360, L6370, L6400, L6450, L6500, L6550, L6570, L6580, L6582, L6584, L6586, L6588, L6590, L6600, L6605, L6610, L6611, L6615, L6616, L6620, L6621, L6623, L6624, L6625, L6628, L6629, L6630, L6632, L6635, L6637, L6638, L6640, L6641, L6642, L6645, L6646, L6647, L6648, L6650, L6655, L6660, L6665, L6670, L6672, L6675, L6676, L6677, L6680, L6682, L6684, L6686, L6687, L6688, L6689, L6690, L6691, L6692, L6693, L6694, L6695, L6696, L6697, L6698, L6700, L6703, L6704, L6706, L6707, L6708, L6709, L6711, L6712, L6713, L6714, L6715, L6721, L6722, L6805, L6810, L6880, L6881, L6882, L6883, L6884, L6885, L6890, L6895, L6900, L6905, L6910, L6915, L6920, L6925, L6930, L6935, L6940, L6945, L6950, L6955, L6960, L6965, L6970, L6975, L7007, L7008, L7009, L7040, L7045, L7170, L7180, L7181, L7185, L7186, L7190, L7191, L7260, L7400, L7401, L7402, L7403, L7404, L7405, L7406, L7499
Selected durable medical equipment (DME)
- Bone growth stimulators
E0747, E0760
- Bone growth stimulator, electrical, noninvasive, spinal
Precertification is performed by Carelon Medical Benefits Management, an independent company.
For additional information, refer to the current version of Medical Policy #00.01.66: Musculoskeletal Services.
- Bone-anchored (osseointegrated) hearing aids
69716, 69719, 69726, 69727, L8690, L8691, L8692, L8693, L8694
- Continuous positive airway pressure (CPAP) devices, bi-level (Bi-PAP) devices, and all supplies
Precertification is performed by Carelon Medical Benefits Management, an independent company.
- Dynamic adjustable and static progressive stretching devices (excludes CPMs)
E1800, E1802, E1805, E1810, E1812, E1825, E1830
- Electric, power, and motorized wheelchairs including custom accessories
E1002, E1003, E1004, E1005, E1006, E1007, E1008, E1009, E1010, E1012, E1239, E2291, E2292, E2293, E2294, E2310, E2311, E2312, E2313, E2321, E2322, E2323, E2324, E2325, E2326, E2327, E2328, E2329, E2330, E2331, E2340, E2341, E2342, E2343, E2351, E2368, E2369, E2370, E2373, E2374, E2375, E2376, E2377, E2603, E2604, E2605, E2606, E2607, E2608, E2609, E2613, E2614, E2615, E2616, E2617, E2620, E2621, E2622, E2623, E2624, E2625, E2626, E2627, E2628, E2629, E2630 K0010, K0011, K0012, K0013, K0014, K0056, K0108, K0813, K0814, K0815, K0816, K0820, K0821, K0822, K0823, K0824, K0825, K0826, K0827, K0828, K0829, K0835, K0836, K0837, K0838, K0839, K0840, K0841, K0842, K0843, K0848, K0849, K0850, K0851, K0852, K0853, K0854, K0855, K0856, K0857, K0858, K0859, K0860, K0861, K0862 K0863, K0864, K0890, K0891, K0898
- Insulin pumps
E0784, E0787, S1034
- Manual wheelchairs with the exception of those that are rented
E0958, E1002, E1003, E1004, E1005, E1006, E1007, E1008, E1009, E1010, E1012, E1031, E1037, E1038, E1039 E1050, E1060,E1070, E1083, E1084, E1085, E1086, E1087, E1088, E1089, E1090, E1092, E1093, E1100, E1110
E1130, E1140, E1150, E1160, E1161, E1170, E1171, E1172, E1180, E1190, E1195, E1200, E1220, E1221, E1222
E1223, E1224, E1229, E1231, E1232, E1233, E1234, E1235, E1236, E1237, E1238, E1240, E1250, E1260, E1270
E1280, E1285, E1290, E1295, E2291, E2292, E2293, E2294, E2295, E2603, E2604, E2605, E2606, E2607, E2608
E2609, E2613,
E2614, E2615, E2616, E2617, E2620, E2621, E2622, E2623, E2624, E2625, E2626, E2627, E2628
E2629, E2630, K0001, K0002, K0003, K0004, K0005, K0006, K0007, K0008, K0009, K0108
- Negative pressure wound therapy
A6550, A9272, E2402, K0743, K0744, K0745, K0746
- Neuromuscular stimulators
E0744, E0745, E0764, E0770
- Power operated vehicles (POV)
E1230, K0800, K0801, K0802, K0812
- Pressure reducing support surfaces including:
- Air fluidized bed
E0194
- Non powered advanced pressure reducing mattress
E0371, E0373
- Powered air flotation bed (low air loss therapy)
E0193, E0372
- Powered pressure reducing mattress
E0277
- Push rim activated power assist devices
E0986
- Repair or replacement of all DME items, as well as orthoses and prosthetics that require precertification - See specific DME, orthoses, and prosthetics categories for Repair or Replacement codes that require precertification.
- Speech generating devices
E2500, E2502, E2504, E2506, E2508, E2510, E2511, E2599, V5336
Medical foods
B4149, B4150, B4152, B4153, B4154, B4155, B4157, B4158, B4159, B4160, B4161, B4162, S9433, S9434, S9435
Hyperbaric oxygen therapy
0413, G0277
In-Lab / Facility sleep studies
Precertification is performed by Carelon Medical Benefits Management, an independent company.
Proton beam therapy
Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).
All transplant procedures, with the exception of corneal transplants
0584T, 0585T, 0586T, 15775, 15776, 27415, 27416, 29866, 29867, 32851, 32852, 32853, 32854, 33935, 33945, 38205, 38206, 38207, 38208, 38209, 38210, 38211, 38212, 38213, 38214, 38215, 38230, 38232, 38240, 38241, 38242, 38243, 44133, 44135, 44136, 44137, 47135, 47140, 47141, 47142, 47399, 48160, 48554, 48556, 50320, 50340, 50360, 50365, 50370, 50380, 50547, G0341, G0342, G0343, S2053, S2054, S2060, S2061, S2065, S2103, S2140, S2142, S2150
Mental health/serious mental illness/substance abuse
- Mental health and serious mental illness treatment (inpatient/partial hospitalization programs/intensive outpatient programs)
- Repetitive transcranial magnetic stimulation (RTMS)
- Substance abuse treatment (inpatient/partial hospitalization programs/intensive outpatient programs)
Autism spectrum disorders
- Applied behavioral analysis
Genetic and genomic tests requiring precertification
Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).
The following list is a guide to the types of genetic and genomic tests that require precertification. Due to the volume of tests, it is not possible to list each test separately. To determine if a test requires precertification, please see the complete procedure code list for details.
Please note: precertification of genetic and genomic tests applies to commercial members only.
Hereditary cancer syndromes
- BRCA gene testing (breast and ovarian cancer syndrome)
- Lynch syndrome gene testing
- Familial adenomatous polyposis gene testing
- PTEN gene testing (Cowden syndrome)
- General cancer type panels (such as colon, breast, or neuroendocrine cancers)
Hereditary heart diseases
- Long QT syndrome gene testing
- Aortic dilation or aneurysm syndrome testing (includes Marfan syndrome)
Other full gene analysis testing
- Cystic fibrosis full gene sequencing and deletion/duplication analysis
- PMP22 full gene sequencing and deletion/duplication analysis (Charcot-Marie-Tooth, hereditary neuropathy)
Tests for many genetic disorders simultaneously
- Expanded carrier screening panels (such as Carrier Status DNA Insight®, Counsyl Family Prep Screen, Pan-Ethnic Carrier Screening)
- Hearing loss panels
- Intellectual disability panels
- Noonan spectrum disorders panels
Specialty oncology tests
- Cancer gene expression or protein signature tests (such as OncotypeDX®, MammaPrint®, Afirma®, Prosigna®, HeproDX™)
- Tumor molecular profiling (such as FoundationOne®, neoTYPE™, OncoPlexDx®, and many others)
- Tissue of origin testing (for cancer of unknown primary)
- PCA3 testing for prostate cancer
Pharmacogenomic tests
- Cytochrome P450 metabolism gene testing (CYP2D6, CYP2C9, CYP2C19)
- Specialized drug response gene panels (such as Assurex GeneSight®, GeneTrait, Genecept®, Millennium PGTSM)
- Warfarin response testing
- MGMT methylation analysis for glioblastoma
Other specialty tests
- Coronary artery disease risk testing (such as CorusCAD®, CardioIQ®, APOE, ACE, KIF6)
- Heart disease risk testing (such as CorusCAD®, CardioIQ®, APOE, ACE, KIF6, MTHFR)
Genome-wide tests
- Microarray studies
- Whole exome testing
- Whole genome testing
- Mitochondrial genome or nuclear testing
ANY genetic test for more than one gene or condition (often includes words like “panel" or “comprehensive" in the name)
ANY genetic test that will be billed with a non-specific procedure code
- Billed with CPT® codes
81400-81408
- Billed with an unlisted code:
81479, 81599, 84999
Specialty drugs requiring precertification
All listed brands and their generic equivalents or biosimilars require precertification. This list is subject to change.
Amyotrophic Lateral Sclerosis agents
- NurOwn® -
J3490, J3590, and C9399
Antineoplastic agents
- Abraxane® -
J9264
- Adstiladrin® -
J9029
- Adcetris® -
J9042
- Anktiva® -
J9028
-
Alymsys® - Q5126 (Note: Ophthalmologic use of Alymsys does not require precertification.)
- Avastin® -
C9257, J9035, and Q5129
(Note: Ophthalmologic use of Avastin does not require precertification. Precertification requirements apply to all FDA-approved biosimilars to this reference product.)
- Avzivi® -
J3490, J3590, and C9399
- Azedra®* -
A9590
- Bizengri® -
J9382
- Blincyto™ -
J9039
- Columvi™ -
J9286
- Cyramza® -
J9308
- Darzalex™ -
J9145
- Darzalex Faspro™ –
J9144
- Datroway® -
C9174
-
Elahere™ - J9063
- Elrexfio™ -
J1323
- Enhertu® -
J9358
- Epkinly™ -
J9321
- Erbitux® -
J9055
- Herceptin® -
J9355
(Precertification requirements apply to all FDA-approved biosimilars to this originator product.)
- Herceptin® Hylecta -
J9356
- Herzuma® -
Q5113
- Imjudo® -
J9347
- Kadcyla® -
J9354
-
Kimmtrak® - J9274
- Kyprolis® -
J9047
- Lunsumio™ -
J9350
- Margenza™ -
J9353
- Monjuvi® -
J9349
- Ogivri™ -
Q5114
- Ontruzant® -
Q5112
-
Opdualag™ - J9298
- Padcev™-
J9177
- Patritumab deruxtecan -
J3490, J3590, and C9399
- Pemfexy™ -
J9304
- Perjeta® -
J9306
- Phesgo™ –
J9316
-
Pluvicto™* -
J3490 and C9399
- Polivy™ -
J9309
- Poteligeo® -
J9204
- Provenge® -
Q2043
- Riabni™ -
Q5123
- Rituxan® -
J9312
(Precertification requirements apply to all FDA-approved biosimilars to this originator product.)
- Rituxan Hycela™ -
J9311
-
Rybrevant™ –
J9061
- Rylaze™ -
J9021
- Rytelo™ -
J0870
- Sarclisa® -
J9227
- Taclantis (pending FDA approval) -
J3490 and C9399
- Talvey™ -
J3055
-
Tecvayli™ -
J9380
- Tivdak™ -
J9273
- Trodelvy® -
J9317
- Vyloy® -
J1326
- Xofigo®* -
A9606
- Yervoy™ -
J9228
- Zepzelca™ –
J9223
- Zevalin®* -
A9543
-
Ziihera® -
J9276
- Zynlonta™
J9359
*
Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).
Anti PD-1/PD-L1 human monoclonal antibodies
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Bavencio® -
J9023
- Camrelizumab (pending FDA approval) -
J3490, J3590, and C9399
- Imfinzi™ -
J9173
- Jemperli™ -
J9272
- Keytruda™ -
J9271
- Libtayo® - J9119
-
Loqtorzi™ -
J3263
- Opdivo® -
J9299
- Opdivo Qvantig™ -
J9289
- Tecentriq™ -
J9022
- Tecentriq Hybreza™ -
J9024
- Unloxcyt™ -
J9275
- Tevimbra® -
J9329
- Zynyz™ -
J9345
Bone-modifying agents
- Evenity™ -
J3111
- Jubbonti® -
Q5136
- Prolia® -
J0897
- Wyost® -
Q5136
- Xgeva® -
J0897
Botulinum toxin agents
Chimeric antigen receptor (CAR-T) therapies
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Abecma® - Q2055
- Aucatzyl® -
Q2058
- Breyanzi® -
Q2054
-
Carvykti™ - Q2056
- Kymriah™ -
Q2042
- Tecartus™ -
Q2053
- Yescarta™ -
Q2041
- Chimeric antigen receptor t-cell (car-t) therapy; car-t cell administration, autologous – 38228
Endocrine/metabolic agents
- Acthar® Gel -
J0801 and J0802
- lanerotide - J1932
- Lutathera®* -
A9513 and A9699
- Sandostatin® LAR -
J2353
- Somatuline® depot -
J1930
- Xenpozyme™ -
J0218
*
Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).
Enzyme replacement agents
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Aldurazyme® -
J1931
- Adzynma -
J7171
- Brineura™ -
J0567
- Cerezyme® -
J1786
- Cinaxadamtase Alfa (pending FDA approval) – J3490, J3590, and C9399
- Cipaglucosidase Alfa (pending FDA approval) –
J3490, J3590, and C9399
- Elaprase® -
J1743
- Elelyso® -
J3060
- Elfabrio® -
J2508
- Fabrazyme® -
J0180
- Kanuma® -
J2840
-
Lamzede® - J0217
-
Lumizyme® - J0221
- Mepsevii™
- J3397
- Naglazyme® -
J1458
- Nexviazyme™ -
J0219
- Pombiliti™ -
J1203
- Replagal®
(pending FDA approval) -
J3490
- Revcovi™
- J3590 and C9399
- Vimizim™ -
J1322
- Vpriv® -
J3385
-
Xenpozyme® - J3590 and C9399
Gene Replacement / Gene Editing Therapies
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit
year.
- Casgevy™ -
J3392
- Eladocagene exuparvovec -
J3490, J3590, and C9399
- Elevidys® -
J1413
- Hemgenix® -
J1411
-
Lenmeldy™ -
J3391
- Luxturna™
- J3398
- Lyfgenia™ -
J3394
- Marnetegragene aututemcel -
J3490, J3590, and C9399
- Prademagene zamikeracel -
J3490, J3590, and C9399
- Roctavian® -
J1412
-
Skysona® -
J3590 and C9399
- Vvjuvek™ -
J3401
- Zolgensma®
- J3399
- Zynteglo® -
J3393
Hemophilia/Coagulation factors
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Advate® -
J7192
- Adynovate® -
J7207
- Afstyla® -
J7210
- Alphanate® -
J7186
- Alphanine SD® -
J7193
- Alprolix® - J7201
- Altuviiio™ -
J7214
- Bebulin VH® -
J7194
- Benefix® -
J7195
- Coagadex® -
J7175
- Corifact® -
J7180
- Eloctate® -
J7205
- Esperoct® -
J7204
- Feiba NF® -
J7198
- Feiba VH® -
J7198
- Fibryga® -
J7177
- Helixate FS® -
J7192
- Hemlibra® -
J7170
- Hemofil-M® -
J7190
- Humate-P® -
J7187
- Hympavzi™ -
J7172
- Idelvion® -
J7202
- Ixinity® -
J7213
- Jivi® -
J7199 and J7208
- Koate-DVI® -
J7190
- Kogenate FS® -J7192
- Kovaltry® -
J7207 and J7211
- Monoclate-P® -
J7190
- Mononine® -
J7193
- Novoeight® -
J7182
- Novoseven RT® -
J7189
- Novoseven® -
J7189
- Nuwiq® -
J7209
- Obizur® -
J7188
- Profilnine SD® -
J7194
- Rebinyn® -
J7203
- Recombinate® -
J7192
- RiaSTAP® -
J7178
- Rixubis® -
J7195 and J7200
- Sevenfact® –
J7212
- Tretten® -
J7181
- Vonvendi® -
J7179 and J7199
- Wilate® -
J7183
- Xyntha® -
J7185
Hyaluronate acid products
- Cingal
(pending FDA approval) -
J3490
- Durolane®
- J7318
- Euflexxa™ -
J7323
- Gel-One® -
J7326
- Gelsyn-3™ -
J7328
- GenVisc 850® -
J7320
- Hyalgan® -
J7321
- Hymovis® -
J7322
- Supartz® -
J7321
- Synojoynt™ -
J7331
- Triluron™ -
J7332
- TriVisc™ -
J7329
- VISCO-3® -
J7321
Immunological agents
- Actemra® -
J3262 (See note below.)
- Benlysta® IV -
J0490
- Cosentyx® IV –
J3247
- Entyvio™ -
J3380 (See note below.)
- Ilumya™ -
J3245
- Imuldosa® -
Q5098
- Omvoh™ -
J2267
- Orencia® IV-
J0129
- Otulfi® -
Q9999
- Pyzchiva® -
Q9996 and Q9997
- Saphnelo™ -
J0491
- Selarsdi™ -
Q9998
- Simponi® Aria -
J1602
-
Skyrizi® IV - J2327
-
Spevigo® -
J1747
- Stelara® - J3357 and J3358
- Steqeyma® - Q5099
- Tofidence™ -
Q5133
- Tremfya® IV -
J1628
- Tyenne® -
Q5135
- Wezlana –
Q5137, Q5138
- Yesintek™ -
Q5100
HCPCS codes J3362 and J3380 will only require precertification when not reported with the JB modifier.
Intravenous Immune Globulin/Subcutaneous Immune Globulin (IVIG/SCIG)
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Intravenous Immune Globulin (IVIG)
- Alyglo™ -
J1552
- Asceniv® -
J1554
- Bivigam® -
J1556
- Flebogamma® -
J1572
- Flebogamma-Dif® -
J1572
- Gammagard Liquid® -
J1569
- Gammagard S/D® -
J1566
- Gammaked® -
J1561
- Gammaplex® -
J1557
- Gamunex-C® -
J1561
- Octagam® -
J1568
- Panzyga® -
J1576
- Privigen® -
J1459
- Subcutaneous Immune Globulin (SCIG)
- Cutaquig® -
J1551
- Cuvitru® -
J1555
- Hizentra® -
J1559
- Hyqvia® -
J1575
- Xembify® -
J1558
Multiple sclerosis agents
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Briumvi™ -
J2329
- Lemtrada® -
J0202
- Ocrevus™ -
J2350
- Ocrevus Zunovo® -
J2351
- Tyruko® -
Q5134
- Tysabri® -
J2323
Myasthemia Gravis Agents
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Rystiggo® -
J9333
- Vyygart™ -
J9332
- Vyygart® Hytrulo -
J9334
Neutropenia
- Efbemalenograstim Alfa (pending FDA approval) -
J3490, J3590, and C9399
- Fulphila™ -
Q5108
-
Fylnetra® -
Q5130
- Granix® -
J1447
- Lapelga
(pending FDA approval) -
J3490, J3590, and C9399
- Neupogen® -
J1442
- Nypozi® -
Q5148
-
Releuko™ - Q5125
-
Rolvedon™ -
J1449
- Ryzneuta® -
J9361
-
Stimufend® -
Q5127
- Udenyca™ -
Q5111
- Ziextenzo® -
Q5120
Ophthalmic agents
- Ahzantive® -
Q5150
- Beovu® -
J0179
- Byooviz™ -
Q5124
-
Cimerli™ -
Q5128
- Enzeevu™ -
Q5149
- Eylea® -
J1078(Precertification requirements apply to all FDA-approved biosimilars to this reference product.)
- Eylea® HD -
J1077 (Precertification requirements apply to all FDA-approved biosimilars to this reference product.)
- Lucentis® -
J2778 (Precertification requirements apply to all FDA-approved biosimilars to this reference product.)
- Opuviz -
Q5153
- Pavblu™ -
Q5147
- Susvimo™-
C2779
- Tepezza® -
J3241
-
Vabysmo® -
J2777
- Yesafili™ -
J3490, J3590, and C9399
Pulmonary arterial hypertension
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Flolan® -
J1325
- Remodulin® -
J3285
- Revatio® -
J3490 and C9399
- Tyvaso® -
J7686
- Uptravi® IV -
J3490 and C9399
- Veletri® -
J1325
- Ventavis® -
Q4074
Respiratory agents
- Cinqair® -
J2786
- Synagis® -
90378
- Xolair® -
J2357
Respiratory enzymes (Alpha-1 antitrypsin)
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Aralast -
J0256
- Glassia™ -
J0257
- Prolastin® -
J0256
- Zemaira® -
J0256
Tumor Infiltrating Lymphocyte (TIL) Therapy
All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
- Amtagvi™ –
J3590, and C9399
- Imdelltra™-
J9026
- Linvoseltamab -
J3490, J3590, and C9399
- Tecelra® -
Q2057
Miscellaneous therapeutic agents
- Adakveo® -
J0791
- Ampligen®
(pending FDA approval) -
J3490
-
Amvuttra™ -
J0225
- Bkemv™ -
Q5152
- Cosela® -
J1448
- Crysvita® - J0584
-
Enjaymo™ - J1302
- Epysqli® -
Q5151
- Evkeeza™ -
J1305
- Exenatide sustained-release ITCA 650
(pending FDA approval) - J3490
- Gamifant® -
J9210
- Givlaari® -
J0223
- Ilaris®
- J0638
- Injectafar® -
J1439
- Krystexxa®
- J2507
- Lantidra® -
J3490, J3590, and C9399
-
Leqvio® - J1306
- Monoferric® -
J1437
- Narsoplimab (pending FDA approval) -
C9399 and J3590
- Niktimvo™ -
J9038
- Onpattro® -
J0222
- Oxlumo™ –
J0224
- Panhemitin® - J1640
- PiaSky® - J1307
- Reblozyl® -
J0896
- Remune -
J3490
- Rethymic™ -
J3590, and C9399
- Soliris® -
J1299
- Spinraza™ -
J2326
- Tzield™ -
J9381
- Ultomiris™ -
J1303
- Uplizna™
– J1823
- Veopoz™ -
J9376
- Vyepti™ -
J3032
- Xiaflex® –
J0775
Revisions
July 1, 2025
The following revisions were incorporated into the July 1, 2025 update.
Additions
Cochlear implant surgery and associated supplies/bone-anchored (osseointegrated) hearing aids, implantable bone conduction hearing aids L8614 Cochlear Device, Includes All Internal and External Components Genetically and bio-engineered skin substitutes for wound care Q4368 Amchothick, per square centimeter Q4370 Aeroguard, per square centimeter Q4371 Neoguard, per square centimeter Q4372 Amchoplast excel, per square centimeter Q4373 Membrane wrap lite, per square centimeter Q4375 Duograft ac, per square centimeter Q4376 Duograft aa, per square centimeter Q4377 Trigraft ft, per square centimeter Q4378 Renew ft matrix, per square centimeter Q4379 Amniodefend ft matrix, per square centimeter Q4380 Advograft one, per square centimeter Q4382 Advograft dual, per square centimeter
Antineoplastic agents Bizengri® -
J9382 Datroway® -
C9174 Vyloy® -
J1326 Ziihera® - J9276 Anti PD-1/PD-L1 human monoclonal antibodies Loqtorzi™ -
J3263 Opdivo Qvantig™ -
J9289 Unloxcyt™ -
J9275 Chimeric antigen receptor (CAR-T) therapies Aucatzyl® -
Q2058
Gene Replacement / Gene Editing Therapies Lenmeldy™ -
J3391
Hemophilia/Coagulation factors Hympavzi™ -
J7172
Immunological agents Cosentyx® IV –
J3247 Imuldosa® -
Q5098 Steqeyma® - Q5099 Yesintek™ -
Q5100
Ophthalmic agents Opuviz –
Q5153
Pulmonary arterial hypertension Uptravi® IV -
J3490 and C9399
_______________________________________________________
Deletions
Antineoplastic agents Loqtorzi™ -
J3263 Vyloy® -
J3590 andC9303 Ziihera® - J3590 and C9302 Zolbetuximab (pending FDA approval) -
J3490, J3590, and C9399
Anti PD-1/PD-L1 human monoclonal antibodies Cosentyx® IV –
J3247 Opdivo Qvantig™ -
J3590 and C9399
Chimeric antigen receptor (CAR-T) therapies Aucatzyl® -
C9301 Obecabtagene autotemcel -
J3490, J3590, and C9399
Gene Replacement / Gene Editing Therapies Beqvez™ -
J1414 Lenmeldy™ -
J3590 and C9399
Hemophilia/Coagulation factors Hympavzi™ -
J3590 and C9304
Neutropenia Nypozi® -
C9173
Ophthalmic agents Opuviz -
J3490, J3590, and C9399 |
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